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My current research is focused on the analysis and modeling of somatic hypermutations (SHM) in B-cells. Particularly, I am interested in specific pattern of SHM in Chronic Lymphocytic Leukemia (CLL) and differences between CLL and normal B-cells.
Additional pursuits include the analysis of longevity genome-wide association study (GWAS). This involves the idea of ‘buffering’ and ‘buffered’ genes which have beneficial or deleterious impacts, respectively. Using the data obtained from GWAS we were able to identify SNPs that fall into either of these two categories.
Finally, we developed a novel correction algorithm which accounts for number of SNPs per gene in GWAS.
Additional pursuits include the analysis of longevity genome-wide association study (GWAS). This involves the idea of ‘buffering’ and ‘buffered’ genes which have beneficial or deleterious impacts, respectively. Using the data obtained from GWAS we were able to identify SNPs that fall into either of these two categories.
Finally, we developed a novel correction algorithm which accounts for number of SNPs per gene in GWAS.